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Literature summary for 4.1.1.50 extracted from

  • Ndjonka, D.; Da'dara, A.; Walter, R.D.; Luersen, K.
    Caenorhabditis elegans S-adenosylmethionine decarboxylase is highly stimulated by putrescine but exhibits a low specificity for activator binding (2003), Biol. Chem., 384, 83-91.
    View publication on PubMed
Search for more literature for 4.1.1.50

Activating Compound

Activating Compound Comment Organism Structure
putrescine enhances activity up to 350fold Caenorhabditis elegans
spermidine 250fold increase of catalytic activity at 2 mM Caenorhabditis elegans
spermine 90fold increase of catalytic activity at 2 mM Caenorhabditis elegans

Protein Variants

Protein Variants Comment Organism
D190N reduced activation by putrescine, spermidine or spermine Caenorhabditis elegans
E194Q strongly enhanced basic activity, little activation by putrescine, spermidine or spermine Caenorhabditis elegans
E274Q slightly enhanced basic activity, reduced activation by putrescine, spermidine or spermine Caenorhabditis elegans
E33Q drastically reduced activation by putrescine, no activation by spermidine or spermine, no complete processing of pro-protein Caenorhabditis elegans
K95A no activation, no complete processing of pro-protein Caenorhabditis elegans
R91A drastically reduced activation by putrescine, spermidine or spermine, no complete processing of pro-protein Caenorhabditis elegans
S128A drastically reduced activation by putrescine, spermidine or spermine Caenorhabditis elegans
S83A no activation, no processing of pro-protein Caenorhabditis elegans
T192A slightly enhanced basic activity, reduced activation by putrescine, spermidine or spermine Caenorhabditis elegans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.115
-
 S-adenosyl-L-methionine in presence of 2 mM putrescine Caenorhabditis elegans
0.47
-
 S-adenosyl-L-methionine in presence of 0.5 mM putrescine Caenorhabditis elegans
1
-
 S-adenosyl-L-methionine in presence of 0.3 mM putrescine Caenorhabditis elegans

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification
-
 Caenorhabditis elegans

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0005
-
 without activator Caenorhabditis elegans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine
-
 Caenorhabditis elegans (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?