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Literature summary for 4.1.1.50 extracted from
- S-Adenosyl-L-methionine decarboxylase of Acanthamoeba castellanii (Neff): purification and properties (1993), Biochem. J., 295, 203-209.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| putrescine | stimulation | Acanthamoeba castellanii |  |
| pyruvate | alpha-subunit contains an N-terminal pyruvoyl group | Acanthamoeba castellanii | |
| spermidine | no effect | Acanthamoeba castellanii | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Berenil | - |
Acanthamoeba castellanii | |
| Ethidium bromide | - |
Acanthamoeba castellanii | |
| Hydroxystilbamidine | - |
Acanthamoeba castellanii | |
| methylglyoxal bis(guanylhydrazone) | - |
Acanthamoeba castellanii | |
| Pentamidine | - |
Acanthamoeba castellanii | |
| Propamidine | - |
Acanthamoeba castellanii | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.03 | - |
S-adenosyl-L-methionine | in presence of 2 mM putrescine | Acanthamoeba castellanii | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 14600 | - |
2 * 32500, alpha, + 2 * 14600, beta, SDS-PAGE | Acanthamoeba castellanii |
| 32500 | - |
2 * 32500, alpha, + 2 * 14600, beta, SDS-PAGE | Acanthamoeba castellanii |
| 88000 | - |
gel filtration | Acanthamoeba castellanii |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Acanthamoeba castellanii | - |
Neff strain | - |
| Acanthamoeba castellanii NEFF | - |
Neff strain | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Acanthamoeba castellanii |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.158 | - |
- |
Acanthamoeba castellanii |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine | - |
Acanthamoeba castellanii | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | - |
Acanthamoeba castellanii NEFF | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 2 * 32500, alpha, + 2 * 14600, beta, SDS-PAGE | Acanthamoeba castellanii |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | 7.8 | - |
Acanthamoeba castellanii |
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