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Literature summary for 4.1.1.50 extracted from
- Purification and characterization of S-adenosyl-L-methionine decarboxylase from mouse mammary gland and liver (1979), Biochemistry, 18, 5541-5548.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| putrescine | stimulation | Mus musculus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| spermidine | - |
Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.02 | 0.11 | S-adenosyl-L-methionine | - |
Mus musculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 32000 | - |
2 * 32000, SDS-PAGE | Mus musculus |
| 68000 | - |
gel filtration | Mus musculus |
| 74000 | - |
sucrose density gradient centrifugation | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine | Mus musculus | key enzyme in polyamine biosynthesis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
| mammary gland | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.102 | - |
- |
Mus musculus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, 10 mM Tris-HCl buffer, pH 7.6, in presence of 0.4 M NaCl and 0.01% deoxycholate, stable for at least 1 month | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine | - |
Mus musculus | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | key enzyme in polyamine biosynthesis | Mus musculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 32000, SDS-PAGE | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
- |
Mus musculus |
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