Application | Comment | Organism |
---|---|---|
medicine | increased quinolic acid levels may result from reduced activity of ACMSD in suicidal subjects. Suicide attempters have reduced picolinic acid levels and a decreased picolinic acid/quinolinic acid ratio in both cerebrospinal fluid and blood. The minor C allele of the ACMSD SNP rs2121337 is more prevalent in suicide attempters and associated with increased cerebrospinal quinolinic acid level | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8TDX5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
cerebrospinal fluid | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | amino-beta-carboxymuconate-semialdehyde-decarboxylase limits quinolinic acid formation by competitive production of the neuroprotective metabolite picolinic acid. Decreased ACMSD activity can lead to excess quinolinic acid | Homo sapiens |