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Literature summary for 4.1.1.45 extracted from

  • Matsuda, H.; Sato, M.; Yakushiji, M.; Koshiguchi, M.; Hirai, S.; Egashira, Y.
    Regulation of rat hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-NAD pathway, by dietary cholesterol and sterol regulatory element-binding protein-2 (2014), Eur. J. Nutr., 53, 469-477.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Rattus norvegicus
-
 2-aminomuconate semialdehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q8R5M5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
 Rattus norvegicus 2-aminomuconate semialdehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ACMSD
-
 Rattus norvegicus
alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase
-
 Rattus norvegicus
picolinic carboxylase
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus the enzyme activity in hypercholesterolemic rats is decreased in liver but not in kidney down
Rattus norvegicus gene expression is positively regulated by SREBP-2 in the hypercholesterolemic rat and rat primary hepatocytes up

General Information

General Information Comment Organism
metabolism the enzyme plays a key role in NAD+ biosynthesis from tryptophan. The enzyme is associated with cholesterol metabolism Rattus norvegicus