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Literature summary for 4.1.1.45 extracted from

  • Fukuoka, S.; Ishiguro, K.; Yanagihara, K.; Tanabe, A.; Egashira, Y.; Sanada, H.; Shibata, K.
    Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and "quinolinate hypothesis" (2002), J. Biol. Chem., 277, 35162-35167.
    View publication on PubMed
Search for more literature for 4.1.1.45

Application

Application Comment Organism
medicine quinolinate, non-enzymatically derived from 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate is a potent endogenous excitotoxin of neuronal cells, whose elevation in brain is implicated in the pathogenesis of various neurodegenerative disorders, ACMSD is the only known enzyme that can process ACMS to a benign catabolite and thus prevent the accumulation of quinolinate Sus scrofa
medicine quinolinate, non-enzymatically derived from 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate is a potent endogenous excitotoxin of neuronal cells, whose elevation in brain is implicated in the pathogenesis of various neurodegenerative disorders, ACMSD is the only known enzyme that can process ACMS to a benign catabolite and thus prevent the accumulation of quinolinate Mus musculus
medicine quinolinate, non-enzymatically derived from 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate is a potent endogenous excitotoxin of neuronal cells, whose elevation in brain is implicated in the pathogenesis of various neurodegenerative disorders, ACMSD is the only known enzyme that can process ACMS to a benign catabolite and thus prevent the accumulation of quinolinate Rattus norvegicus
medicine quinolinate, non-enzymatically derived from 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate is a potent endogenous excitotoxin of neuronal cells, whose elevation in brain is implicated in the pathogenesis of various neurodegenerative disorders, ACMSD is the only known enzyme that can process ACMS to a benign catabolite and thus prevent the accumulation of quinolinate Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
cDNA cloning, expressed in COS7 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
p-chloromercuribenzoate
-
 Homo sapiens
p-chloromercuribenzoate
-
 Mus musculus
p-chloromercuribenzoate
-
 Rattus norvegicus
p-chloromercuribenzoate
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Sus scrofa tryptophan-niacine pathway 2-aminomuconate-6-semialdehyde + CO2
-
 ?
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Mus musculus tryptophan-niacine pathway 2-aminomuconate-6-semialdehyde + CO2
-
 ?
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Rattus norvegicus tryptophan-niacine pathway 2-aminomuconate-6-semialdehyde + CO2
-
 ?
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Homo sapiens tryptophan-niacine pathway 2-aminomuconate-6-semialdehyde + CO2
-
 ?
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate Mus musculus ICR tryptophan-niacine pathway 2-aminomuconate-6-semialdehyde + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8TDX5 human
-
Mus musculus Q8R519 mouse, ICR strain
-
Mus musculus ICR Q8R519 mouse, ICR strain
-
Rattus norvegicus Q8R5M5 rat
-
Sus scrofa
-
 pig
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa
-
 Mus musculus
-
 Rattus norvegicus
partial Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
 Sus scrofa 2-aminomuconate-6-semialdehyde + CO2
-
 ?
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
 Mus musculus 2-aminomuconate-6-semialdehyde + CO2
-
 ?
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
 Rattus norvegicus 2-aminomuconate-6-semialdehyde + CO2
-
 ?
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
 Homo sapiens 2-aminomuconate-6-semialdehyde + CO2
-
 ?
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate tryptophan-niacine pathway Sus scrofa 2-aminomuconate-6-semialdehyde + CO2
-
 ?
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate tryptophan-niacine pathway Mus musculus 2-aminomuconate-6-semialdehyde + CO2
-
 ?
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate tryptophan-niacine pathway Rattus norvegicus 2-aminomuconate-6-semialdehyde + CO2
-
 ?
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate tryptophan-niacine pathway Homo sapiens 2-aminomuconate-6-semialdehyde + CO2
-
 ?
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate
-
 Mus musculus ICR 2-aminomuconate-6-semialdehyde + CO2
-
 ?
2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate tryptophan-niacine pathway Mus musculus ICR 2-aminomuconate-6-semialdehyde + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ACMSD
-
 Sus scrofa
ACMSD
-
 Mus musculus
ACMSD
-
 Rattus norvegicus
ACMSD
-
 Homo sapiens