Literature summary for 4.1.1.38 extracted from

Wood, H.G.; O'Brien, W.E.; Michaels, G.
Properties of carboxytransphosphorylase; pyruvate, phosphate dikinase; pyrophosphate-phosphofructikinase and pyrophosphate-acetate kinase and their roles in the metabolism of inorganic pyrophosphate (1977), Adv. Enzymol. Relat. Areas Mol. Biol., 45, 85-155.

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Inhibitors

Inhibitors	Comment	Organism	Structure
diphosphate	-	Propionibacterium freudenreichii subsp. shermanii
DL-malate	-	Propionibacterium freudenreichii subsp. shermanii
fumarate	-	Propionibacterium freudenreichii subsp. shermanii
Imidodiphosphate	competitive with respect to diphosphate	Propionibacterium freudenreichii subsp. shermanii
Methylene diphosphonate	competitive with respect to diphosphate	Propionibacterium freudenreichii subsp. shermanii
thiols	formation of pyruvate from phosphoenolpyruvate and phosphate	Propionibacterium freudenreichii subsp. shermanii

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Co2+	Mn2+, Mg2+ or Co2+ required	Propionibacterium freudenreichii subsp. shermanii
Mg2+	Mn2+, Mg2+ or Co2+ required	Propionibacterium freudenreichii subsp. shermanii
Mn2+	Mn2+, Mg2+ or Co2+ required	Propionibacterium freudenreichii subsp. shermanii

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
97000	-	monomeric enzyme form	Propionibacterium freudenreichii subsp. shermanii
224000	-	dimeric enzyme form, equilibrium sedimentation	Propionibacterium freudenreichii subsp. shermanii
430000	-	-	Propionibacterium freudenreichii subsp. shermanii

Organism

Organism	UniProt	Comment	Textmining
Propionibacterium freudenreichii subsp. shermanii	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphate + phosphoenolpyruvate + CO2	-	Propionibacterium freudenreichii subsp. shermanii	diphosphate + oxaloacetate	-	?
phosphoenolpyruvate + phosphate	-	Propionibacterium freudenreichii subsp. shermanii	pyruvate + diphosphate	-	?

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Release 2023.1 (January 2023)