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Literature summary for 4.1.1.37 extracted from

  • Mukerji, S.K.; Pimstone, N.R.
    In vitro studies of the mechanism of inhibition of rat liver uroporphyrinogen decarboxylase activity by ferrous iron under anaerobic conditions (1986), Arch. Biochem. Biophys., 224, 619-629.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoate)
-
Rattus norvegicus
Fe2+ 0.45 mM Fe(NH4)2, 50% inhibition under anaerobic conditions in the dark. Competitive with uroporphyrinogen I and uroporphyrinogen II as substrates. Preincubation with 5-COOH-porphyrinogen protects Rattus norvegicus
Hg2+
-
Rattus norvegicus
Zn2+
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0003
-
6-COOH-porphyrinogen I
-
Rattus norvegicus
0.00133
-
5-COOH-porphyrinogen I
-
Rattus norvegicus
0.00182
-
uroporphyrinogen III
-
Rattus norvegicus
0.00285
-
6-COOH-porphyrinogen I
-
Rattus norvegicus
0.00318
-
Uroporphyrinogen I
-
Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-COOH-porphyrinogen I
-
Rattus norvegicus Coproporphyrinogen I + CO2
-
?
6-COOH-porphyrinogen I
-
Rattus norvegicus Coproporphyrinogen I + CO2
-
?
7-COOH-porphyrinogen I
-
Rattus norvegicus Coproporphyrinogen I + CO2
-
?
uroporphyrinogen I
-
Rattus norvegicus coproporphyrinogen I + 4 CO2
-
?
Uroporphyrinogen III
-
Rattus norvegicus Coproporphyrinogen III + 4 CO2
-
?