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Literature summary for 4.1.1.37 extracted from
- Purification and characterization of bovine hepatic uroporphyrinogen decarboxylase (1983), Biochemistry, 22, 4664-4672.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,2'-dipyridyl disulfide | - |
Bos taurus |  |
| 5,5'-dithiobis(2-nitrobenzoate) | - |
Bos taurus | |
| Al3+ | - |
Bos taurus | |
| Co2+ | - |
Bos taurus | |
| Cu2+ | - |
Bos taurus | |
| Fe2+ | - |
Bos taurus | |
| iodoacetamide | - |
Bos taurus | |
| Pb2+ | - |
Bos taurus | |
| Zn2+ | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00042 | - |
6-COOH-porphyrinogen I | - |
Bos taurus | |
| 0.00043 | - |
5-COOH-porphyrinogen III | - |
Bos taurus | |
| 0.00044 | - |
7-COOH-porphyrinogen I | - |
Bos taurus | |
| 0.00064 | - |
6-COOH-porphyrinogen III | - |
Bos taurus | |
| 0.00079 | - |
8-COOH-porphyrinogen I | - |
Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.016 | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-COOH-porphyrinogen III | - |
Bos taurus | Coproporphyrinogen III + CO2 | - |
? | |
| 6-COOH-porphyrinogen I | - |
Bos taurus | Coproporphyrinogen I + CO2 | - |
? | |
| 6-COOH-porphyrinogen III | - |
Bos taurus | Coproporphyrinogen III + CO2 | - |
? | |
| 7-COOH-porphyrinogen I | - |
Bos taurus | Coproporphyrinogen I + CO2 | - |
? | |
| 8-COOH-porphyrinogen I | - |
Bos taurus | Coproporphyrinogen I + CO2 | - |
? | |
| additional information | - |
Bos taurus | additional information | the pattern of accumulation of intermediate 7-COOH-porphyrinogens, 6-COOH-porphyrinogens and 5-COOH-porphyrinogens and final coproporphyrinogen decarboxylation products is affected by the ratio of substrate concentration of uroporphyrinogen I or II to enzyme concentration. Under physiological conditions, where the uroporphyrinogen to enzyme ratio is low, the substrate is nearly quantitatively decarboxylated, and the major product is coproporphyrinogen | ? | |
| uroporphyrinogen I | - |
Bos taurus | coproporphyrinogen I + 4 CO2 | - |
? | |
| Uroporphyrinogen III | - |
Bos taurus | Coproporphyrinogen III + 4 CO2 | - |
? | |
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