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Literature summary for 4.1.1.33 extracted from

  • Weerasinghe, S.; Samantha Dassanayake, R.
    Simulation of structural and functional properties of mevalonate diphosphate decarboxylase (MVD) (2010), J. Mol. Model., 16, 489-498.
    View publication on PubMed
Search for more literature for 4.1.1.33

Protein Variants

Protein Variants Comment Organism
L79P molecular dynamics simutation of the mutated enzyme, it is suggested that the temperature sensitive mutant phenotype of Saccharomyces cerevisiae is a result of a significant conformational change associates with the Leu 79 to Pro mutation Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
triflouromevalonate diposphate molecular dynamics simulation for the inhibitor bound complex Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 5-diphosphomevalonate Saccharomyces cerevisiae
-
 ADP + phosphate + isopentenyl diphosphate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P32377
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-diphosphomevalonate
-
 Saccharomyces cerevisiae ADP + phosphate + isopentenyl diphosphate + CO2
-
 ?
additional information molecular dynamics simulation to characterize the active site of mevalonate 5-diphosphate decarboxylase to predict a probable mechanism in the transition state Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
Mevalonate 5-diphosphate decarboxylase
-
 Saccharomyces cerevisiae
scMVD
-
 Saccharomyces cerevisiae