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Literature summary for 4.1.1.33 extracted from
- Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity (2007), J. Mol. Biol., 371, 540-553.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) cells | Trypanosoma brucei |
| expressed in Escherichia coli BL21(DE3) cells | Staphylococcus aureus |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Trypanosoma brucei |
| hanging drop vapour diffusion method using 0.1 M Tris-HCl (pH 8.0), 1.8 M sodium malonate | Staphylococcus aureus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 36800 | - |
SDS-PAGE | Trypanosoma brucei |
| 36800 | - |
SDS-PAGE | Staphylococcus aureus |
| 44100 | - |
SDS-PAGE | Saccharomyces cerevisiae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | P32377 | - |
- |
| Staphylococcus aureus | A0A0H2XIV6 | - |
- |
| Trypanosoma brucei | Q388P2 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni2+ chelating column chromatography and HiTrapQ Sepharose column chromatography | Trypanosoma brucei |
| Ni2+ chelating column chromatography and HiTrapQ Sepharose column chromatography | Staphylococcus aureus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 5-diphosphomevalonate | - |
Saccharomyces cerevisiae | ADP + phosphate + isopentenyl diphosphate + CO2 | - |
? |  |
| ATP + 5-diphosphomevalonate | - |
Trypanosoma brucei | ADP + phosphate + isopentenyl diphosphate + CO2 | - |
? | |
| ATP + 5-diphosphomevalonate | - |
Staphylococcus aureus | ADP + phosphate + isopentenyl diphosphate + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | in solution, gel filtration | Staphylococcus aureus |
| monomer | in solution, gel filtration | Trypanosoma brucei |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MDD | - |
Saccharomyces cerevisiae |
| MDD | - |
Trypanosoma brucei |
| MDD | - |
Staphylococcus aureus |
| mevalonate diphosphate decarboxylase | - |
Saccharomyces cerevisiae |
| mevalonate diphosphate decarboxylase | - |
Trypanosoma brucei |
| mevalonate diphosphate decarboxylase | - |
Staphylococcus aureus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Saccharomyces cerevisiae | |
| ATP | - |
Trypanosoma brucei | |
| ATP | - |
Staphylococcus aureus | |
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Release 2023.1 (January 2023)
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