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Literature summary for 4.1.1.33 extracted from

  • Qiu, Y.; Li, D.
    Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase (2006), Org. Lett., 8, 1013-1016.
    View publication on PubMed
Search for more literature for 4.1.1.33

Inhibitors

Inhibitors Comment Organism Structure
(2E)-3,7-dimethylocta-2,6-dien-1-yl 2-(4-hydroxy-4-methyl-6-oxotetrahydro-2H-pyran-2-yl)ethyl diphosphate
-
 Rattus norvegicus
(2E)-3,7-dimethylocta-2,6-dien-1-yl 4-(4-hydroxy-4-methyl-6-oxotetrahydro-2H-pyran-2-yl)butyl diphosphate
-
 Rattus norvegicus
P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-diphosphomevalonate
-
 Rattus norvegicus ADP + phosphate + isopentenyl diphosphate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
MDD
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.002
-
-
 Rattus norvegicus P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
0.0026
-
-
 Rattus norvegicus (2E)-3,7-dimethylocta-2,6-dien-1-yl 2-(4-hydroxy-4-methyl-6-oxotetrahydro-2H-pyran-2-yl)ethyl diphosphate
0.0065
-
-
 Rattus norvegicus (2E)-3,7-dimethylocta-2,6-dien-1-yl 4-(4-hydroxy-4-methyl-6-oxotetrahydro-2H-pyran-2-yl)butyl diphosphate