Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ATP | required | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DTNB | 10 mM, 60% inhibition | Mus musculus | |
iodoacetic acid | 10 mM, 15% inhibition | Mus musculus | |
NEM | 10 mM, 40% inhibition | Mus musculus | |
p-chloromercuribenzene sulfonic acid | 10 mM, 50% inhibition | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.01 | - |
mevalonate diphosphate | pH 7.2 | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | divalent metal ion required, Mg2+ can be substituted by Mn2+ or Co2+ | Mus musculus | |
Mg2+ | divalent metal ion required, Mg2+ can be substituted by Mn2+ or Co2+ | Mus musculus | |
Mn2+ | divalent metal ion required, Mg2+ can be substituted by Mn2+ or Co2+ | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
46000 | - |
2 * 46000, SDS-PAGE | Mus musculus |
100000 | - |
gel filtration | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.2327 | - |
- |
Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 5-diphosphomevalonate | - |
Mus musculus | ADP + phosphate + isopentenyl diphosphate + CO2 | - |
? | |
CTP + 5-diphosphomevalonate | 12% of the activity with ATP | Mus musculus | CDP + phosphate + isopentenyl diphosphate + CO2 | - |
? | |
GTP + 5-diphosphomevalonate | 25% of the activity with ATP | Mus musculus | GDP + phosphate + isopentenyl diphosphate + CO2 | - |
? | |
UTP + 5-diphosphomevalonate | 13% of the activity with ATP | Mus musculus | UDP + phosphate + isopentenyl diphosphate + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 46000, SDS-PAGE | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4 | 7 | - |
Mus musculus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4 | 10 | pH 3.0: about 5% of maximal activity, pH 4.0-7.0: maximal activity, pH 10.0: about 40% of maximal activity | Mus musculus |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Mus musculus | isoelectric focusing | - |
5 |