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Literature summary for 4.1.1.33 extracted from

  • Michihara, A.; Akasaki, K.; Yamori, Y.; Tsuji, H.
    Purification and characterization of mouse mevalonate pyrophosphate decarboxylase (2002), Biol. Pharm. Bull., 25, 302-306.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ATP required Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
DTNB 10 mM, 60% inhibition Mus musculus
iodoacetic acid 10 mM, 15% inhibition Mus musculus
NEM 10 mM, 40% inhibition Mus musculus
p-chloromercuribenzene sulfonic acid 10 mM, 50% inhibition Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
mevalonate diphosphate pH 7.2 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ divalent metal ion required, Mg2+ can be substituted by Mn2+ or Co2+ Mus musculus
Mg2+ divalent metal ion required, Mg2+ can be substituted by Mn2+ or Co2+ Mus musculus
Mn2+ divalent metal ion required, Mg2+ can be substituted by Mn2+ or Co2+ Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
46000
-
2 * 46000, SDS-PAGE Mus musculus
100000
-
gel filtration Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.2327
-
-
Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-diphosphomevalonate
-
Mus musculus ADP + phosphate + isopentenyl diphosphate + CO2
-
?
CTP + 5-diphosphomevalonate 12% of the activity with ATP Mus musculus CDP + phosphate + isopentenyl diphosphate + CO2
-
?
GTP + 5-diphosphomevalonate 25% of the activity with ATP Mus musculus GDP + phosphate + isopentenyl diphosphate + CO2
-
?
UTP + 5-diphosphomevalonate 13% of the activity with ATP Mus musculus UDP + phosphate + isopentenyl diphosphate + CO2
-
?

Subunits

Subunits Comment Organism
dimer 2 * 46000, SDS-PAGE Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4 7
-
Mus musculus

pH Range

pH Minimum pH Maximum Comment Organism
4 10 pH 3.0: about 5% of maximal activity, pH 4.0-7.0: maximal activity, pH 10.0: about 40% of maximal activity Mus musculus

pI Value

Organism Comment pI Value Maximum pI Value
Mus musculus isoelectric focusing
-
5