Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.1.29 extracted from

  • Park, E.; Park, S.Y.; Dobkin, C.; Schuller-Levis, G.
    Development of a novel cysteine sulfinic acid decarboxylase knockout mouse dietary taurine reduces neonatal mortality (2014), J. Amino Acids, 2014, 346809 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.29

Cloned(Commentary)

Cloned (Comment) Organism
the murine CSAD gene is located on chromosome 15 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of CSAD knockout mice, chimeric CSAD KO mice are produced by injection of cells from a gene trap ES cell line (XP0392) into C57BL/6 (B6) blastocysts which are implanted into a pseudopregnant B6 mouse. Nine chimeric mice are mated with B6 in the animal colony. Agouti mice produced by this mating are back-crossed to B6 and offsprings are genotyped using PCR, overview. Although CSAD-/- generation (G)1 and G2 survive, offspring from G2 CSAD-/- have low brain and liver taurine concentrations and most die within 24 hrs of birth. Taurine concentrations in G3 CSAD-/- born from G2 CSAD-/- treated with taurine in the drinking water are restored and survival rates of G3 CSAD-/- increase from 15% to 92%. The mRNA expression of CDO, ADO, and TauT is not different in CSAD-/- compared to wild-type, and CSAD mRNA is not expressed in CSAD-/-. Expression of Gpx 1 and 3 is increased significantly in CSAD-/- and restored to normal levels with taurine supplementation. Lactoferrin and the prolactin receptor are significantly decreased in CSAD-/-. The prolactin receptor is restored with taurine supplementation Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-sulfino-L-alanine Mus musculus
-
 hypotaurine + CO2
-
 ?
3-sulfino-L-alanine Mus musculus C57BL/6
-
 hypotaurine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9DBE0
-
-
Mus musculus C57BL/6 Q9DBE0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-sulfino-L-alanine
-
 Mus musculus hypotaurine + CO2
-
 ?
3-sulfino-L-alanine
-
 Mus musculus C57BL/6 hypotaurine + CO2
-
 ?

Subunits

Subunits Comment Organism
? x * 51000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
CSAD
-
 Mus musculus
Cysteine sulfinic acid decarboxylase
-
 Mus musculus