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Literature summary for 4.1.1.29 extracted from

  • Nagasaki, T.; Hongo, Y.; Koito, T.; Nakamura-Kusakabe, I.; Shimamura, S.; Takaki, Y.; Yoshida, T.; Maruyama, T.; Inoue, K.
    Cysteine dioxygenase and cysteine sulfinate decarboxylase genes of the deep-sea mussel Bathymodiolus septemdierum possible involvement in hypotaurine synthesis and adaptation to hydrogen sulfide (2015), Amino Acids, 47, 571-578 .
    View publication on PubMed
Search for more literature for 4.1.1.29

Cloned(Commentary)

Cloned (Comment) Organism
gene CSAD, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic analysis, quantitative real-time PCR enzyme expression analysis Bathymodiolus septemdierum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-sulfino-L-alanine Bathymodiolus septemdierum
-
 hypotaurine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Bathymodiolus septemdierum A0A0A8J1X6 obtained at hydrothermal vent field in Myojin Knoll (depth, 1228 m), Japan
-

Source Tissue

Source Tissue Comment Organism Textmining
gill
-
 Bathymodiolus septemdierum
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additional information tissue-specific expression pattern of CSAD isozymes, overview. The enzyme is ubiquitously expressed with highest level of enzyme in gills Bathymodiolus septemdierum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-sulfino-L-alanine
-
 Bathymodiolus septemdierum hypotaurine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
BsCSAD
-
 Bathymodiolus septemdierum
CSAD
-
 Bathymodiolus septemdierum
Cysteine sulfinate decarboxylase
-
 Bathymodiolus septemdierum

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Bathymodiolus septemdierum

Expression

Organism Comment Expression
Bathymodiolus septemdierum the enzyme mRNA level in the gill is not significantly changed by exposure to sulfides or thiosulfate additional information

General Information

General Information Comment Organism
evolution CSAD is a member of the type II PLP-dependent amino acid decarboxylase carboxylase family Bathymodiolus septemdierum
physiological function the gills of Bathymodiolus septemdierum maintain high levels of expression of the CSAD gene regardless of ambient sulfide level and accumulate hypotaurine continuously to protect against sudden exposure to high level of sulfide. Since CSAD gene expression is observed in all the tissues examined, it is likely that hypotaurine is synthesized extensively in mussel tissues Bathymodiolus septemdierum