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Literature summary for 4.1.1.29 extracted from

  • Kerr, T.; Matsumoto, Y.; Matsumoto, H.; Xie, Y.; Hirschberger, L.; Stipanuk, M.; Anakk, S.; Moore, D.; Watanabe, M.; Kennedy, S.; Davidson, N.
    Cysteine sulfinic acid decarboxylase regulation: A role for farnesoid X receptor and small heterodimer partner in murine hepatic taurine metabolism (2014), Hepatol. Res., 44, E218-228.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
nutrition mice supplemented with dietary cholate exhibit reduced hepatic cysteine sulfinic acid decarboxylase mRNA while those receiving cholestyramine exhibit increased mRNA. Activation of farnesoid X receptor suppresses cysteine sulfinic acid decarboxylase mRNA expression whereas cysteine sulfinic acid decarboxylase expression is increased in mice lacking farnesoid X receptor small heterodimer partner Shp. Hepatic hypotaurine concentration, the product of cysteine sulfinic acid decarboxylase, is higher in Shp-/- mice with a corresponding increase in serum taurine conjugated bile acids. Fibroblast growth factor 19 administration suppresses hepatic cholesterol 7-alpha-hydroxylase CYP7A1 mRNA but does not change cysteine sulfinic acid decarboxylase mRNA expression Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
liver
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Mus musculus
-

Expression

Organism Comment Expression
Mus musculus bile acids regulate cysteine sulfinic acid decarboxylase mRNA expression in a feedback fashion via mechanisms involving farnesoid X receptor small heterodimer partner Shp and farnesoid X receptor additional information