Literature summary for 4.1.1.28 extracted from

Hoefig, C.S.; Renko, K.; Piehl, S.; Scanlan, T.S.; Bertoldi, M.; Opladen, T.; Hoffmann, G.F.; Klein, J.; Blankenstein, O.; Schweizer, U.; Koehrle, J.
Does the aromatic L-amino acid decarboxylase contribute to thyronamine biosynthesis? (2012), Mol. Cell. Endocrinol., 349, 195-201.

Search for more literature for 4.1.1.28

Application

Application	Comment	Organism
medicine	enzyme is responsible for thyronamine biosynthesis via decarboxylation of thyroid hormone. In addition, patients with aromatic L-amino acid decarboxylase-deficiency display thyronamines in plasma at levels similar to those of healthy controls	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P20711	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	under all reaction conditions tested, the enzyme fails to catalyze thyroid hormone decarboxylation. The enzyme is responsible for Thyronamine biosynthesis via decarboxylation of thyroid hormone	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
AADC	-	Homo sapiens

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Release 2023.1 (January 2023)