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Literature summary for 4.1.1.28 extracted from

  • Ren, J.; Zhang, Y.; Jin, H.; Yu, J.; Zhou, Y.; Wu, F.; Zhang, W.
    Novel inhibitors of human DOPA decarboxylase extracted from Euonymus glabra Roxb. (2014), ACS Chem. Biol., 9, 897-903.
    View publication on PubMed
Search for more literature for 4.1.1.28

Application

Application Comment Organism
analysis development o a high-throughput assay for testing of inhibitors Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-[1-[4-hydroxy-5-[3-(3-hydroxy-4-methoxyphenyl)propyl]-2-methoxyphenyl]-3-(4-hydroxy-3-methoxyphenyl)propyl]-5-methoxycyclohexa-2,5-diene-1,4-dione inhibitor isolated from Euonymus glabra Roxb. Homo sapiens
3-[2-hydroxy-5-[3-(4-hydroxy-3-methoxyphenyl)propyl]-4-methoxyphenyl]-2-[3-(4-hydroxy-3-methoxyphenyl)-2-oxopropyl]-5-methoxycyclohexa-2,5-diene-1,4-dione inhibitor isolated from Euonymus glabra Roxb., structural analogue of dopamine. Compound is able to suppress the activity of dopa decarboxylase and dopamine levels in purified enzyme and cell-based assays Homo sapiens
additional information 4-benzoquinone might be the crucial chemical moiety for binding and inhibiting human DOPA decarboxylase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0115
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-[2-hydroxy-5-[3-(4-hydroxy-3-methoxyphenyl)propyl]-4-methoxyphenyl]-2-[3-(4-hydroxy-3-methoxyphenyl)-2-oxopropyl]-5-methoxycyclohexa-2,5-diene-1,4-dione
0.0216
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-[1-[4-hydroxy-5-[3-(3-hydroxy-4-methoxyphenyl)propyl]-2-methoxyphenyl]-3-(4-hydroxy-3-methoxyphenyl)propyl]-5-methoxycyclohexa-2,5-diene-1,4-dione