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Literature summary for 4.1.1.28 extracted from

  • Davis, M.M.; Primrose, D.A.; Hodgetts, R.B.
    A member of the p38 mitogen-activated protein kinase family is responsible for transcriptional induction of Dopa decarboxylase in the epidermis of Drosophila melanogaster during the innate immune response (2008), Mol. Cell. Biol., 28, 4883-4895.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.28

Activating Compound

Activating Compound Comment Organism Structure
additional information A conserved AP-1 (JNK activated transcription factor complex) binding upstream of the DDC transcription start site is necessary to induce DDC transcription Drosophila melanogaster
additional information aseptic wounding of larvae or adults does not lead to DDC transcriptional induction, unlike in embryos where DDC activity at the edge of the wound contributes to the formation of a melanin clot Drosophila melanogaster
additional information Transcription of the dopa decarboxylase gene is induced in response to gram-negative and gram-positive septic injury, but not aseptic wounding. Ddc transcripts are detectible within 2 h and remain high for several hours following infection with either gram-negative (Escherichia coli) or gram-positive (Staphylococcus aureus) bacteria. Ddc transcription depends on a previously uncharacterized member of the p38 mitogen-activated protein kinase family, p38c Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Dopa Drosophila melanogaster
-
 dopamine + CO2 dopamine has a neural role and is metabolized to produce melanin and sclerotin in epidermal tissues ?
additional information Drosophila melanogaster DDC activity is required in the epidermis for the synthesis of dopamine that is metabolized to produce reactive quinones that exert killing effects on invading bacteria ?
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 ?
additional information Drosophila melanogaster DDC plays a role in the Drosophila innate immune response in larvae and adults ?
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 ?
additional information Drosophila melanogaster dopa decarboxylase plays an essential role in wound healing in the Drosophila embryo ?
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 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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-
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Source Tissue

Source Tissue Comment Organism Textmining
epidermis transcription of DDC is induced when larvae or adults are infected, transcription is induced throughout the epidermis and not specifically at the site of infection Drosophila melanogaster
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head DDC transcription is induced strongly in the flies that are septically injured with Eschericia coli or Staphylococcos aureus Drosophila melanogaster
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thorax DDC transcription is induced strongly in the flies that are septically injured with Eschericia coli or Staphylococcos aureus Drosophila melanogaster
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Dopa
-
 Drosophila melanogaster dopamine + CO2 dopamine has a neural role and is metabolized to produce melanin and sclerotin in epidermal tissues ?
additional information DDC activity is required in the epidermis for the synthesis of dopamine that is metabolized to produce reactive quinones that exert killing effects on invading bacteria Drosophila melanogaster ?
-
 ?
additional information DDC plays a role in the Drosophila innate immune response in larvae and adults Drosophila melanogaster ?
-
 ?
additional information dopa decarboxylase plays an essential role in wound healing in the Drosophila embryo Drosophila melanogaster ?
-
 ?

Synonyms

Synonyms Comment Organism
DDC
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 Drosophila melanogaster
DOPA decarboxylase
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 Drosophila melanogaster