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Literature summary for 4.1.1.28 extracted from
- Renal dopaminergic system activity in rat remnant kidney up to twenty-six weeks after surgery (2009), Life Sci., 84, 409-414.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | a decrease in urinary levels of dopamine and in renal AADC activity at 20 twenty-six weeks after renal mass ablation | Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.2 | - |
L-3,4-dihydroxyphenylalanine | determined in homogenates of renal cortex of 3/4 nephrectomized rats after 26 weeks | Rattus norvegicus |  |
| 2.6 | - |
L-3,4-dihydroxyphenylalanine | determined in homogenates of renal cortex of sham surgery rats (control) after 10 weeks | Rattus norvegicus | |
| 2.6 | - |
L-3,4-dihydroxyphenylalanine | determined in homogenates of renal cortex of sham surgery rats (control) after 26 weeks | Rattus norvegicus | |
| 2.9 | - |
L-3,4-dihydroxyphenylalanine | determined in homogenates of renal cortex of 3/4 nephrectomized rats after 10 weeks | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-3,4-Dihydroxyphenylalanine | Rattus norvegicus | the renal dopaminergic system is highly dynamic and the basic mechanisms for the regulation of this system mainly depends on the availability of L-dopa, its fast decarboxylation into dopamine, precise cell outward amine transfer mechanisms, dopamine interaction with specific receptor and accurate intracellular signal transduction | Dopamine + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
normotensive male Wistar-Han rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | renal dopaminergic system activity in rat (3/4 nephrectomized) kidney up to 26 weeks after surgery | Rattus norvegicus | - |
| proximale tubular epithelium | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.00000113 | - |
determined in homogenates of renal cortex of 3/4 nephrectomized rats after 26 weeks | Rattus norvegicus |
| 0.00001427 | - |
determined in homogenates of renal cortex of sham surgery rats (control) after 10 weeks | Rattus norvegicus |
| 0.00001653 | - |
determined in homogenates of renal cortex of sham surgery rats (control) after 26 weeks | Rattus norvegicus |
| 0.00001893 | - |
determined in homogenates of renal cortex of 3/4 nephrectomized rats after 10 weeks | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-3,4-Dihydroxyphenylalanine | the renal dopaminergic system is highly dynamic and the basic mechanisms for the regulation of this system mainly depends on the availability of L-dopa, its fast decarboxylation into dopamine, precise cell outward amine transfer mechanisms, dopamine interaction with specific receptor and accurate intracellular signal transduction | Rattus norvegicus | Dopamine + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AADC | - |
Rattus norvegicus |
| Aromatic L-amino acid decarboxylase | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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