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Literature summary for 4.1.1.28 extracted from

  • Matsushita, N.; Misu, Y.; Goshima, Y.
    In vivo antagonism of the behavioral responses to L-3-,4-dihydroxyphenylalanine by L-3-,4-dihydroxyphenylalanine cyclohexyl ester in conscious rats (2009), Eur. J. Pharmacol., 605, 109-113.
    View publication on PubMed
Search for more literature for 4.1.1.28

Inhibitors

Inhibitors Comment Organism Structure
3'-hydroxybenzylhydrazine NSD-1015, a central aromatic L-amino acid decarboxylase inhibitor Rattus norvegicus
Benserazide peripheral inhibitor Rattus norvegicus
additional information L-3,4-dihydroxyphenylalanine (100 mg/kg) increases the striatal dopamine content but elicits no effect on locomotor activity in the presence of benserazide (50 mg/kg i.p.), a peripheral AADC inhibitor. L-3,4-dihydroxyphenylalanine increases the dopamine content in the presence of 3'-hydroxybenzylhydrazine to a maximal degree similar to that in the presence of benserazide. L-3,4-dihydroxyphenylalanine cyclohexyl ester is a suitable L-3,4-dihydroxyphenylalanine antagonist that would be available under in vivo experimental conditions.; L-3,4-dihydroxyphenylalanine cyclohexyl ester would antagonize the behavioral responses of conscious rats to L-3,4-dihydroxyphenylalanine in the presence of 3'-hydroxybenzylhydrazine. L-3,4-dihydroxyphenylalanine cyclohexyl ester elicits a dose-dependent partial antagonism against the increase in locomotor activity induced by L-3,4-dihydroxyphenylalanine. A low dose of L-3,4-dihydroxyphenylalanine cyclohexyl ester (10 mg/kg) elicits full antagonism against the potentiating effect of a non-effective dose of L-3,4-dihydroxyphenylalanine (20 mg/kg) on the increase in locomotor activity induced by a dopamine D2 agonist quinpirole (0.3 mg/kg s.c.). L-3,4-dihydroxyphenylalanine cyclohexyl ester elicits full antagonism against licking behavior induced by L-3,4-dihydroxyphenylalanine. Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-3,4-Dihydroxyphenylalanine Rattus norvegicus DOPA, plays a role in the neuromodulation of behavior Dopamine + CO2
-
 ?
additional information Rattus norvegicus DOPA cyclohexyl ester is an antagonist of DOPA ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-3,4-Dihydroxyphenylalanine DOPA, plays a role in the neuromodulation of behavior Rattus norvegicus Dopamine + CO2
-
 ?
additional information DOPA cyclohexyl ester is an antagonist of DOPA Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
AADC
-
 Rattus norvegicus
Aromatic L-amino acid decarboxylase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Rattus norvegicus