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Literature summary for 4.1.1.28 extracted from

  • Ito, S.; Nakayama, T.; Ide, S.; Ito, Y.; Oguni, H.; Goto, Y.; Osawa, M.
    Aromatic L-amino acid decarboxylase deficiency associated with epilepsy mimicking non-epileptic involuntary movements (2008), Dev. Med. Child Neurol., 50, 876-878.
    View publication on PubMed
Search for more literature for 4.1.1.28

Application

Application Comment Organism
medicine Because epileptic attacks can be treated with appropriate antiepileptic drugs, a confirmation whether patients with AADC deficiency have both non-epileptic and epileptic seizures in varying proportions, is necessary. The differentiation of epileptic seizures from involuntary non-epileptic movements, such as short-lasting dystonic attacks, chorea, or myoclonus, is indispensable for the adequate treatment of patients with AADC deficiency. Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,4-Dihydroxyphenylalanine Homo sapiens enzyme is involved in the biosynthesis of monoamine neurotransmitters Dopamine + CO2
-
 ?
5-hydroxytryptophan Homo sapiens
-
 5-hydroxytryptamine + CO2 serotonin ?
additional information Homo sapiens aromatic L-amino acid decarboxylase deficiency is a rare inborn error of neurotransmitter biosynthesis that leads to a combined deficiency of catecholamines and serotonin and is characterized by global developmental delay, involuntary movements, and autonomic dysfunction ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4-Dihydroxyphenylalanine enzyme is involved in the biosynthesis of monoamine neurotransmitters Homo sapiens Dopamine + CO2
-
 ?
5-hydroxytryptophan
-
 Homo sapiens 5-hydroxytryptamine + CO2 serotonin ?
additional information aromatic L-amino acid decarboxylase deficiency is a rare inborn error of neurotransmitter biosynthesis that leads to a combined deficiency of catecholamines and serotonin and is characterized by global developmental delay, involuntary movements, and autonomic dysfunction Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
AADC
-
 Homo sapiens
Aromatic L-amino acid decarboxylase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Homo sapiens