Any feedback?
Literature summary for 4.1.1.28 extracted from
- Role of tyrosine, DOPA and decarboxylase enzymes in the synthesis of monoamines in the brain of the locust (2002), Neurochem. Int., 41, 9-16.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | stimulates decarboxylation of DOPA | Locusta migratoria |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (2S)-2-amino-3-(3-hydroxyphenyl)-2-methylpropanoic acid | - |
Locusta migratoria | |
| (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoic acid | - |
Locusta migratoria | |
| 3-hydroxy-benzylhydrazine | - |
Locusta migratoria | |
| 3-iodo-L-tyrosine | - |
Locusta migratoria | |
| alpha-methyl-2,4-dihydroxyphenylalanine | - |
Locusta migratoria | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.052 | - |
3,4-dihydroxyphenylalanine | pH 7.0, 32°C | Locusta migratoria | |
| 0.084 | - |
L-tyrosine | pH 7.0, 32°C | Locusta migratoria | |
| 0.23 | - |
5-hydroxytryptophan | pH 7.0, 32°C | Locusta migratoria | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 112000 | - |
gel filtration | Locusta migratoria |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3,4-dihydroxyphenylalanine | Locusta migratoria | regulation of the ganglionic dopamine level | ? + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Locusta migratoria | - |
migratory locust, subspecies migratorioides R.F. | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Locusta migratoria |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3,4-dihydroxyphenylalanine | - |
Locusta migratoria | 4-(2-aminoethyl)benzene-1,2-diol + CO2 | - |
? | |
| 3,4-dihydroxyphenylalanine | regulation of the ganglionic dopamine level | Locusta migratoria | ? + CO2 | - |
? | |
| 5-hydroxytryptophan | - |
Locusta migratoria | 5-hydroxytryptamine + CO2 | - |
? | |
| L-tryptophan | - |
Locusta migratoria | tryptamine + CO2 | - |
? | |
| L-Tyrosine | - |
Locusta migratoria | Tyramine + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 5HTP decarboxylase | - |
Locusta migratoria |
| DOPA decarboxylase | - |
Locusta migratoria |
| DOPA/5HTP decarboxylase | - |
Locusta migratoria |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
5-hydroxytryptophan as substrate | Locusta migratoria |
| 7 | 7.4 | 2,4-dihydroxyphenylalanine as substrate | Locusta migratoria |
| 7.4 | 7.47 | L-tyrosine as substrate | Locusta migratoria |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Locusta migratoria | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
