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Literature summary for 4.1.1.28 extracted from
- First fungal aromatic L-amino acid decarboxylase from a paclitaxel-producing Penicillium raistrickii (1999), Mycologia, 91, 619-626.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not inhibited by L-alpha-fluoromethyltyrosine and L-alpha-fluoromethyl(3,4-dihydroxyphenyl)alanine | Penicillium raistrickii |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.049 | - |
L-tryptophan | pH 5.0-5.6, 36°C | Penicillium raistrickii |  |
| 0.099 | - |
L-phenylalanine | pH 5.0-5.6, 36°C | Penicillium raistrickii | |
| 1.064 | - |
L-tyrosine | pH 5.0-5.6, 36°C | Penicillium raistrickii | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 125000 | - |
SDS-PAGE | Penicillium raistrickii |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan | Penicillium raistrickii | - |
tryptamine + CO2 | - |
? | |
| L-tryptophan | Penicillium raistrickii H10BA2 | - |
tryptamine + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| no activity in Penicillium raistrickii | - |
strain ATCC 46878 | - |
| Penicillium raistrickii | - |
H10BA2 | - |
| Penicillium raistrickii H10BA2 | - |
H10BA2 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Penicillium raistrickii |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
specific activity 10455 nkatal mg-1 | Penicillium raistrickii |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-phenylalanine | - |
Penicillium raistrickii | phenylethylamine + CO2 | - |
? | |
| L-phenylalanine | - |
Penicillium raistrickii H10BA2 | phenylethylamine + CO2 | - |
? | |
| L-tryptophan | - |
Penicillium raistrickii | tryptamine + CO2 | - |
? | |
| L-tryptophan | - |
Penicillium raistrickii H10BA2 | tryptamine + CO2 | - |
? | |
| L-Tyrosine | - |
Penicillium raistrickii | Tyramine + CO2 | - |
? | |
| L-Tyrosine | - |
Penicillium raistrickii H10BA2 | Tyramine + CO2 | - |
? | |
| additional information | no enzyme activity detected with D-phenylalanine, L-5-hydroxytryptophan or L-histidine | Penicillium raistrickii | ? | - |
? | |
| additional information | no enzyme activity detected with D-phenylalanine, L-5-hydroxytryptophan or L-histidine | Penicillium raistrickii H10BA2 | ? | - |
? | |
| o-fluorophenylalanine | - |
Penicillium raistrickii | o-fluorophenylethylamine + CO2 | - |
? | |
| o-fluorophenylalanine | - |
Penicillium raistrickii H10BA2 | o-fluorophenylethylamine + CO2 | - |
? | |
| p-fluorophenylalanine | - |
Penicillium raistrickii | p-fluorophenylethylamine + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 125000, SDS-PAGE | Penicillium raistrickii |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Aromatic L-amino acid decarboxylase | - |
Penicillium raistrickii |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 36 | - |
- |
Penicillium raistrickii |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 5.6 | - |
Penicillium raistrickii |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Penicillium raistrickii | isoelectric focusing gel | - |
6.2 |
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