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Literature summary for 4.1.1.25 extracted from

  • Blumenthal, E.M.
    Isoform- and cell-specific function of tyrosine decarboxylase in the Drosophila Malpighian tubule (2009), J. Exp. Biol., 212, 3802-3809.
    View publication on PubMed
Search for more literature for 4.1.1.25

Protein Variants

Protein Variants Comment Organism
additional information the mutant allele of Tdc1, Tdc1f03311, reduces expression of the mature Tdc1 transcript by greater than 100fold Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Tyrosine Drosophila melanogaster
-
 Tyramine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
malpighian tubule the non-neuronal isoform of TDC, Tdc1, is expressed in the principal cells of the Malpighian tubule Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Tyrosine
-
 Drosophila melanogaster Tyramine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
TDC
-
 Drosophila melanogaster

General Information

General Information Comment Organism
malfunction Malpighian tubules isolated from Tdc1f03311 homozygous flies show no significant depolarization of their transepithelial potential or diuresis in response to tyrosine while retaining normal sensitivity to tyramine, the null mutant allele of the neuronal TDC isoform Tdc2 has no effect on either tyrosine or tyramine sensitivity Drosophila melanogaster
physiological function synthesis of tyramine by Tdc1 in the principal cells of the Malpighian tubule is required for physiological responses to tyrosine Drosophila melanogaster