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Literature summary for 4.1.1.23 extracted from

  • Purohit, M.K.; Poduch, E.; Wei, L.W.; Crandall, I.E.; To, T.; Kain, K.C.; Pai, E.F.; Kotra, L.P.
    Novel cytidine-based orotidine-5-monophosphate decarboxylase inhibitors with an unusual twist (2012), J. Med. Chem., 55, 9988-9997.
    View publication on PubMed
Search for more literature for 4.1.1.23

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens
-
 Plasmodium falciparum

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure in complex with inhibitor (5-(4-amino-3-oxido-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)-methyl dihydrogen phosphate. Compared to cytosin, the pyrimidine portion exhibits changes in the atomic arrangement. The oxygen atom migrates from N3 to N4 or the C5 position of the cytosine ring. These rearranged nucleotides are each bound to the enzyme in a 2?-endo,syn conformation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(5-(4-amino-3-oxido-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)-methyl dihydrogen phosphate i.e. CMP-N3-oxide Homo sapiens
(5-(4-amino-3-oxido-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)-methyl dihydrogen phosphate i.e. CMP-N3-oxide Plasmodium falciparum
CMP weak inhibitor Homo sapiens
CMP weak inhibitor Plasmodium falciparum
UMP
-
 Homo sapiens
UMP
-
 Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Homo sapiens P11172
-
-
Plasmodium falciparum Q8IJH3 isolate 3D7
-

Synonyms

Synonyms Comment Organism
ODCase
-
 Homo sapiens
ODCase
-
 Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.022
-
 (5-(4-amino-3-oxido-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)-methyl dihydrogen phosphate pH 7.5, 22°C Plasmodium falciparum
0.028
-
 (5-(4-amino-3-oxido-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl)-methyl dihydrogen phosphate pH 7.5, 22°C Homo sapiens
0.21
-
 UMP pH 7.5, 22°C Plasmodium falciparum
0.22
-
 UMP pH 7.5, 22°C Homo sapiens
1.4
-
 CMP pH 7.5, 22°C Homo sapiens