Cloned (Comment) | Organism |
---|---|
gene pyrF, organization in the pyr operon, DNA and amino acid sequence determination and analysis, expression analysis, expression in Escherichia coli | Treponema denticola |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a null mutant, allelic replacement mutagenesis of pyrF, phenotype, overview, unlike the wild-type strain, an isogenic pyrF mutant is resistant to 5-fluoroorotic acid | Treponema denticola |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Uracil | strong feedback inhibition | Treponema denticola |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Treponema denticola | the enzyme is required for 5-fluoroorotic acid toxicity | ? | - |
? | |
Orotidine 5'-phosphate | Treponema denticola | the enzyme is required for de novo pyrimidine synthesis catalyzing the key final step in de novo synthesis of UMP | UMP + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
no activity in Treponema pallidum | - |
- |
- |
Treponema denticola | - |
strain ATCC 35405, single copy gene pyrF or TDE2110 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is required for 5-fluoroorotic acid toxicity | Treponema denticola | ? | - |
? | |
Orotidine 5'-phosphate | - |
Treponema denticola | UMP + CO2 | - |
? | |
Orotidine 5'-phosphate | the enzyme is required for de novo pyrimidine synthesis catalyzing the key final step in de novo synthesis of UMP | Treponema denticola | UMP + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
OMP decarboxylase | - |
Treponema denticola |
orotidine-5-monophosphate decarboxylase | - |
Treponema denticola |