Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-histidine | Homo sapiens | - |
histamine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P19113 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fundic mucosa | - |
Homo sapiens | - |
gastric adenocarcinoma cell | - |
Homo sapiens | - |
gastric mucosa | the tumours are classified based on clinico-pathological criteria | Homo sapiens | - |
additional information | histidine decarboxylase (HDC) expression in healthy and neoplastic gastric neuroendocrine cells in relationship to the main histamine metabolite, immunoreactive localization study, overview | Homo sapiens | - |
neuroendocrine tumor cell | human oxyntic mucosa contains four major types of neuroendocrine cells: ECL, ghrelin, serotonin and somatostatin cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-histidine | - |
Homo sapiens | histamine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HDC | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | human oxyntic mucosa contains four major types of neuroendocrine cells (ECL, ghrelin, serotonin and somatostatin cells). ECL cells are the most abundant type, and they produce histamine. The histamine-synthesizing ability of ECL cells is based on cytosolic HDC. Histamine might be transported by VMAT-2 into the secretory vesicles | Homo sapiens |