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Literature summary for 4.1.1.22 extracted from

  • Bessho, Y.; Iwakoshi-Ukena, E.; Tachibana, T.; Maejima, S.; Taniuchi, S.; Masuda, K.; Shikano, K.; Kondo, K.; Furumitsu, M.; Ukena, K.
    Characterization of an avian histidine decarboxylase and localization of histaminergic neurons in the chicken brain (2014), Neurosci. Lett., 578, 106-110 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene hdc, cDNA is cloned from chicken hypothalamic mRNA, sequence comparisons, quantitative real-time PCR enzyme expression analysis, DNA and amino acid sequence determination and anlysis, recombinant expression, the expressed protein shows high enzymatic activity Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-histidine Gallus gallus
-
histamine + CO2
-
?

Organism

Organism UniProt Comment Textmining
Gallus gallus A0A068Q816
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain in the tuberomammillary nucleus of the posterior hypothalamus Gallus gallus
-
hypothalamus highly expressed in the hypothalamic infundibulum, the cells containing HDC mRNA are localized in the medial mammillary nucleus of the hypothalamic infundibulum Gallus gallus
-
neuron histaminergic Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-histidine
-
Gallus gallus histamine + CO2
-
?

Synonyms

Synonyms Comment Organism
HDC
-
Gallus gallus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Gallus gallus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Gallus gallus

General Information

General Information Comment Organism
physiological function neuronal histamine exerts anorexigenic effects in chicks Gallus gallus