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Literature summary for 4.1.1.22 extracted from
- Inhibitory activity of the flower buds of Lonicera japonica Thunb. against histamine production and L-histidine decarboxylase in human keratinocytes (2014), Molecules, 19, 8212-8219 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| enzyme expression analysis | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 53000 | - |
active enzyme form | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-histidine | Homo sapiens | - |
histamine + CO2 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P19113 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epidermis | - |
Homo sapiens | - |
| keratinocyte | epidermal, three-dimensional keratinocyte culture | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-histidine | - |
Homo sapiens | histamine + CO2 | - |
? | |
| additional information | enzyme immunoassay for detection of histamine production | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HDC | - |
Homo sapiens |
| L-Histidine decarboxylase | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Homo sapiens | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | both flower buds of Lonicera japonica and chlorogenic acid have inhibitory activities against the expression of 53-kDa HDC and histamine production in human epidermal keratinocytes. Chlorogenic acid shows a weaker effect on histamine production than that of flower buds of Lonicera japonica suggesting that other chemical constituents besides chlorogenic acid might contribute to the inhibitory activities. Chlorogenic acid might have an effect on the histamine production in other cells as well such as mast cells in addition to keratinocytes in the epidermis | down |
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