Cloned (Comment) | Organism |
---|---|
quantitative PCR enzyme expression analysis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-histidine | Homo sapiens | - |
histamine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P19113 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | - |
Homo sapiens | - |
HaCaT cell | - |
Homo sapiens | - |
keratinocyte | two-dimensional culture | Homo sapiens | - |
additional information | keratinocytes express abundant HDC protein, and the levels increase in atopic skin | Homo sapiens | - |
skin | atopic | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-histidine | - |
Homo sapiens | histamine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HDC | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | ultraviolet B and surfactant exposure induce the expression of histamine-synthesizing enzyme histidine decarboxylase in keratinocytes. Lipopolysaccharide, house dust mite (HDM) extract, and cytokines, which are implicated in allergic inflammation, promote the expression of the enzyme and upregulate histamine levels in keratinocytes | up |
General Information | Comment | Organism |
---|---|---|
malfunction | filaggrin expression in cultured keratinocytes increased following histamine depletion. Histidine decarboxylase expression is increased in the epidermis of patients with eczema | Homo sapiens |
physiological function | lipopolysaccharide, house dust mite (HDM) extract, and cytokines, which are implicated in allergic inflammation, promote the expression of the enzyme and upregulate histamine levels in keratinocytes. Actively produced histamine influences keratinocyte differentiation, suggesting functional relevance of the axis to atopic dermatitis. HDC expression in keratinocytes is increased in atopic dermatitis | Homo sapiens |