Cloned (Comment) | Organism |
---|---|
expression in COS7 cell | Homo sapiens |
expression in COS7 cell | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
D543A/D544A | mutation in conserved di-aspartate motif. Mutation does not lead to a loss in levels of any of the processed isoforms | Rattus norvegicus |
D551A/D552A | mutation in conserved di-aspartate motif. Mutation does not lead to a loss in levels of any of the processed isoforms | Homo sapiens |
DD513A/D514A | mutation in conserved di-aspartate motif. Mutation does not lead to a loss in levels of any of the processed isoforms | Homo sapiens |
DD519A/D520A | mutation in conserved di-aspartate motif. Mutation does not lead to a loss in levels of any of the processed isoforms | Rattus norvegicus |
additional information | mutation of an EEAPD motif at amino acids 556-560 of the human hHDC protein leads to a decrease in the 59 kDa processed band | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | enzyme undergoes processing with a major processed band of 59 kDa being observed in addition to a number of minor bands. Processing to the 59 kDa band is caspase-6 dependent | Homo sapiens |
proteolytic modification | the protein is processed into major 63, 54 and 58/59 kDa doublet bands. Processing at the HDC SKD 501/502/503 site is likely to be caspase-dependent | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
testis | - |
Homo sapiens | - |