Activating Compound | Comment | Organism | Structure |
---|---|---|---|
HdcB | HdcB catalyses the maturation of pyruvoyl-dependent histidine decarboxylase by cleavage of the proenzyme which results in the formation of the pyruvoyl prosthetic group | Streptococcus thermophilus |
Cloned (Comment) | Organism |
---|---|
expressed in Lactococcus lactis strain NZ9000 and Escherichia coli DH5alpha cells | Streptococcus thermophilus |
Protein Variants | Comment | Organism |
---|---|---|
S82A | the HdcA mutant mimics the proenzyme | Streptococcus thermophilus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
12000 | - |
1 * 24000 + 1 * 12000, mature enzyme, SDS-PAGE | Streptococcus thermophilus |
24000 | - |
1 * 24000 + 1 * 12000, mature enzyme, SDS-PAGE | Streptococcus thermophilus |
37000 | - |
x * 37000, uncleaved proenzyme, SDS-PAGE | Streptococcus thermophilus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptococcus thermophilus | - |
CHCC1524 | - |
Purification (Comment) | Organism |
---|---|
Ni2+-NTA column chromatography | Streptococcus thermophilus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-histidine | - |
Streptococcus thermophilus | histamine + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 37000, uncleaved proenzyme, SDS-PAGE | Streptococcus thermophilus |
heterodimer | 1 * 24000 + 1 * 12000, mature enzyme, SDS-PAGE | Streptococcus thermophilus |
Synonyms | Comment | Organism |
---|---|---|
HdcA | - |
Streptococcus thermophilus |
pyruvoyl-dependent histidine decarboxylase | - |
Streptococcus thermophilus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
Pyruvoyl group | dependent on | Streptococcus thermophilus |