Literature summary for 4.1.1.22 extracted from

Moya-Garcia, A.; Rodriguez-Agudo, D.; Hayashi, H.; Medina, M.; Urdiales, J.; Sanchez-Jimenez, F.
Analysis of mammalian histidine decarboxylase dimerization interface reveals an electrostatic hotspot important for catalytic site topology and function (2011), J. Chem. Theory Comput., 7, 1935-1942.

Search for more literature for 4.1.1.22

Cloned(Commentary)

Cloned (Comment)	Organism
-	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
C316V	the mutant shows 34% activity compared to the wild type enzyme	Rattus norvegicus
D315N	no enzymatic activity	Rattus norvegicus
D315V	no enzymatic activity	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
phenyl-Sepharose column chromatography, DEAE column chromatography, and hydroxyapatite column chromatography	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-histidine	-	Rattus norvegicus	histamine + CO2	-	?

Subunits

Subunits	Comment	Organism
homodimer	-	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
HDC	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Rattus norvegicus

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Release 2023.1 (January 2023)