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Literature summary for 4.1.1.22 extracted from
- Food components inhibiting recombinant human histidine decarboxylase activity (2007), J. Agric. Food Chem., 55, 299-304.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-coumaric acid | slight inhibition | Homo sapiens |  |
| caffeic acid | slight inhibition | Homo sapiens | |
| curcumin | slight inhibition | Homo sapiens | |
| epicatechin | - |
Homo sapiens | |
| epicatechin gallate | competitive versus L-histidine | Homo sapiens | |
| epigallocatechin | - |
Homo sapiens | |
| epigallocatechin gallate | time-dependent inhibition, only under aerobic conditions | Homo sapiens | |
| gallic acid | slight inhibition | Homo sapiens | |
| kaempferol | slight inhibition | Homo sapiens | |
| methylgallate | slight inhibition | Homo sapiens | |
| additional information | poor inhibition by procatechiuc acid, ferulic acid, chlorogenic acid, and ellagic acid, no inhibition by luteorin, apigenin and rutin | Homo sapiens | |
| myricetin | - |
Homo sapiens | |
| phlorizin | slight inhibition | Homo sapiens | |
| quercetin | slight inhibition | Homo sapiens | |
| rosmarinic acid | - |
Homo sapiens | |
| Sinapic acid | slight inhibition | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-histidine | Homo sapiens | histamine is a bioactive amine acting as a neurotransmitter as well as a chemical mediator | histamine + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0002 | - |
purified recombinant enzyme from Saccharomyces cerevisiae | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-histidine | histamine is a bioactive amine acting as a neurotransmitter as well as a chemical mediator | Homo sapiens | histamine + CO2 | - |
? | |
| L-histidine | substrate-specific | Homo sapiens | histamine + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HDC | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01 | - |
epicatechin gallate | pH 6.8, 37°C, recombinant enzyme, versus L-histidine | Homo sapiens | |
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Release 2023.1 (January 2023)
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