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Literature summary for 4.1.1.22 extracted from
- Immunohistochemical detection of histidine decarboxylase in neoplastic mast cells in patients with systemic mastocytosis (2006), Hum. Pathol., 37, 439-447.
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | HDC can be used as an immunohistochemical marker for the detection of immature neoplastic mast cells in patients with mast cell-proliferative disorders | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| quantitative expression analysis in mast cells of different maturation stage of patients with systemic mastocytosis, overview | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| alpha-Fluoromethylhistidine | alpha-FMH, specific inhibitor of HDC | Homo sapiens |  |
| additional information | treatment of mast cells in systemic mastocytosis with pharmacologic inhibitors prednisone, IFNalpha, and 2CdA only slightly inhibit expression of HDC, overview | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-histidine | Homo sapiens | HDC is the key enzyme involved in histamine production | histamine + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| basophil | in basophilic leukemia | Homo sapiens | - |
| bone marrow | from patients with mastocytosis | Homo sapiens | - |
| HMC-1 cell | - |
Homo sapiens | - |
| marrow cell | immature, low expression level in basophilic leukemia | Homo sapiens | - |
| mast cell | neoplastic mast cells in patients with systemic mastocytosis, including MC leukemia and MC sarcoma, expression in mast cells of different maturation stage, immunohistochemic detection and quantitative expression analysis | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-histidine | - |
Homo sapiens | histamine + CO2 | - |
? | |
| L-histidine | HDC is the key enzyme involved in histamine production | Homo sapiens | histamine + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HDC | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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