Literature summary for 4.1.1.22 extracted from

Rodriguez-Caso, C.; Rodriguez-Agudo, D.; Moya-Garcia, A.A.; Fajardo, I.; Medina, M.A.; Subramaniam, V.; Sanchez-Jimenez, F.
Local changes in the catalytic site of mammalian histidine decarboxylase can affect its global conformation and stability (2003), Eur. J. Biochem., 270, 4376-4387.

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Cloned(Commentary)

Cloned (Comment)	Organism
cDNA encoding for residues 1-512 of HDC	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-histidine	Rattus norvegicus	-	histamine + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	74000 Da precursor is most probably processed to a carboxy truncated form of 53000-58000 Da	Rattus norvegicus

Purification (Commentary)

Purification (Comment)	Organism
recombinant HDC	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-histidine	-	Rattus norvegicus	histamine + CO2	-	?

Subunits

Subunits	Comment	Organism
dimer	2 * 53000-58000, SDS-PAGE, the exact sequence of each monomer is not known	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
HDC	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Rattus norvegicus

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Release 2023.1 (January 2023)