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Literature summary for 4.1.1.21 extracted from

  • Meyer, E.; Leonard, N.J.; Bhat, B.; Stubbe, J.; Smith, J.M.
    Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway (1992), Biochemistry, 31, 5022-5032.
    View publication on PubMed
Search for more literature for 4.1.1.21

Cloned(Commentary)

Cloned (Comment) Organism
-
 Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
17000
-
 x * 17000, purE encoded protein, + x * 39000, purK encoded protein, SDS-PAGE. PurE has an octameric MW of 126000 by gel filtration. PurK has a dimeric MW of 79000 by gel filtration Escherichia coli
39000
-
 x * 17000, purE encoded protein, + x * 39000, purK encoded protein, SDS-PAGE. PurE has an octameric MW of 126000 by gel filtration. PurK has a dimeric MW of 79000 by gel filtration Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-(5-Phosphoribosyl)-5-aminoimidazole + CO2 Escherichia coli sixth step in the purine biosynthetic pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-(5-Phosphoribosyl)-5-aminoimidazole + CO2
-
 Escherichia coli 1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxylate
-
 ?
1-(5-Phosphoribosyl)-5-aminoimidazole + CO2 sixth step in the purine biosynthetic pathway Escherichia coli ?
-
 ?

Subunits

Subunits Comment Organism
? x * 17000, purE encoded protein, + x * 39000, purK encoded protein, SDS-PAGE. PurE has an octameric MW of 126000 by gel filtration. PurK has a dimeric MW of 79000 by gel filtration Escherichia coli