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Literature summary for 4.1.1.20 extracted from

  • Bie, P.; Yang, X.; Zhang, C.; Wu, Q.
    Identification of small-molecule inhibitors of Brucella diaminopimelate decarboxylase by using a high-throughput screening assay (2020), Front. Microbiol., 10, 2936.
    View publication on PubMed
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Application

Application Comment Organism
analysis development of a quantitative SDH-DAPDC coupled assay and adaptation for use in a 348-well format Brucella melitensis

Inhibitors

Inhibitors Comment Organism Structure
2-(3-chloro-2-methylanilino)benzoic acid 0.04 mM, 44% inhibition, MIC for growth of Brucella melitensis 0.025 mM Brucella melitensis
4-imino-4-[2-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-3-methylbutanamide 0.04 mM, 47.3% inhibition, MIC for growth of Brucella melitensis 0.05 mM Brucella melitensis
bis(azanido)platinum-cyclobutane-1,1-dicarboxylic acid 0.04 mM, 65% inhibition, MIC for growth of Brucella melitensis 0.0002 mM Brucella melitensis
N-(2-chloro-6-methylphenyl)-2-([6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino)-1,3-thiazole-5-carboxamide 0.04 mM, 67% inhibition, MIC for growth of Brucella melitensis 0.1 mM Brucella melitensis
N-[1-(3-chlorophenyl)-2-hydroxyethyl]-4-[5-chloro-2-[(propan-2-yl)amino]pyridin-4-yl]-1H-pyrrole-2-carboxamide 0.04 mM, 47% inhibition, MIC for growth of Brucella melitensis 0.025 mM Brucella melitensis

Organism

Organism UniProt Comment Textmining
Brucella melitensis Q8YJJ9 biotype 1
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Brucella melitensis 16M Q8YJJ9 biotype 1
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Subunits

Subunits Comment Organism
? x * 40000, SDS-PAGE Brucella melitensis