Literature summary for 4.1.1.20 extracted from

Ray, S.S.; Bonanno, J.B.; Rajashankar, K.R.; Pinho, M.G.; He, G.; De Lencastre, H.; Tomasz, A.; Burley, S.K.
Cocrystal structures of diaminopimelate decarboxylase: mechanism, evolution, and inhibition of an antibiotic resistance accessory factor (2002), Structure, 10, 1499-1508.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Methanocaldococcus jannaschii

Crystallization (Commentary)

Crystallization (Comment)	Organism
co-crystals of DAPDC and azelaic acid and L-lysine at 2.6 A and 2.0 A resolution, respectively, hanging drop vapor-diffusion, 12% polyethylene glycol 6000, 100 mm Tris-Cl, pH 8.0, 20 mM MgCl2 and 10 mM L-lysine	Methanocaldococcus jannaschii

Inhibitors

Inhibitors	Comment	Organism	Structure
1,5-Diaminopentane	-	Methanocaldococcus jannaschii
1,6-diaminohexane	-	Methanocaldococcus jannaschii
1,7-Diaminoheptane	-	Methanocaldococcus jannaschii
adipic acid	-	Methanocaldococcus jannaschii
azelaic acid	-	Methanocaldococcus jannaschii
caproic acid	-	Methanocaldococcus jannaschii

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
50000	-	x * 50000, mass spectrometry	Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
meso-2,6-Diaminoheptanedioate	Methanocaldococcus jannaschii	last step in L-lysine biosynthesis	L-Lysine + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Methanocaldococcus jannaschii	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant DAPDC	Methanocaldococcus jannaschii

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
meso-2,6-Diaminoheptanedioate	-	Methanocaldococcus jannaschii	L-Lysine + CO2	-	?
meso-2,6-Diaminoheptanedioate	last step in L-lysine biosynthesis	Methanocaldococcus jannaschii	L-Lysine + CO2	-	?

Subunits

Subunits	Comment	Organism
?	x * 50000, mass spectrometry	Methanocaldococcus jannaschii

Synonyms

Synonyms	Comment	Organism
DAPDC	-	Methanocaldococcus jannaschii

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0024	-	1,6-diaminohexane	-	Methanocaldococcus jannaschii
0.0025	-	1,7-Diaminoheptane	-	Methanocaldococcus jannaschii
0.004	-	1,5-Diaminopentane	-	Methanocaldococcus jannaschii
0.089	-	azelaic acid	-	Methanocaldococcus jannaschii
0.13	-	adipic acid	-	Methanocaldococcus jannaschii
0.21	-	caproic acid	-	Methanocaldococcus jannaschii

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Release 2026.1 (March 2026)