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Literature summary for 4.1.1.19 extracted from

  • Paulson, N.B.; Gilbertsen, A.J.; Dalluge, J.J.; Welchlin, C.W.; Hughes, J.; Han, W.; Blackwell, T.S.; Laguna, T.A.; Williams, B.J.
    The arginine decarboxylase pathways of host and pathogen interact to impact inflammatory pathways in the lung (2014), PLoS ONE, 9, e111441 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.19

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine Mus musculus
-
 agmatine + CO2
-
 ?
L-arginine Homo sapiens
-
 agmatine + CO2
-
 ?
L-arginine Pseudomonas aeruginosa
-
 agmatine + CO2
-
 ?
L-arginine Pseudomonas aeruginosa ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1
-
 agmatine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Pseudomonas aeruginosa Q9HUX1
-
-
Pseudomonas aeruginosa ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1 Q9HUX1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BEAS-2B cell bronchial cell line Homo sapiens
-
lung enzyme activity and agmatine levels in human sputum peak during cystic fibrosis illness, decrease with treatment, and is positively correlated with inflammatory cytokines Mus musculus
-
lung enzyme activity and agmatine levels in human sputum peak during cystic fibrosis illness, decrease with treatment, and is positively correlated with inflammatory cytokines. Bacterial pathways of agmatine metabolism are able to impact the agmatine levels within the lung during infection Homo sapiens
-
RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine
-
 Mus musculus agmatine + CO2
-
 ?
L-arginine
-
 Homo sapiens agmatine + CO2
-
 ?
L-arginine
-
 Pseudomonas aeruginosa agmatine + CO2
-
 ?
L-arginine
-
 Pseudomonas aeruginosa ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1 agmatine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ADC
-
 Mus musculus
ADC
-
 Homo sapiens
ADC
-
 Pseudomonas aeruginosa
SpeA
-
 Pseudomonas aeruginosa

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Mus musculus
pyridoxal 5'-phosphate
-
 Homo sapiens
pyridoxal 5'-phosphate
-
 Pseudomonas aeruginosa

Expression

Organism Comment Expression
Mus musculus arginine decarboxylase has been shown to be upregulated from the macrophage-like cell line RAW-264.7 in response to lipopolysaccharides and cytokines resulting in more intracellular agmatine. Bacterial agmatine secretion after infection with Pseudomonas aeruginosa is evident in changes in the inflammatory phenotype including increased total cell count up
Homo sapiens enzyme activity and agmatine levels in human sputum peak during cystic fibrosis illness, decrease with treatment, and is positively correlated with inflammatory cytokines up

General Information

General Information Comment Organism
metabolism agmatine is synthesized by the arginine decarboxylase pathway, but is essentially undetectable if the aguBA operon is left intact Mus musculus
metabolism agmatine is synthesized by the arginine decarboxylase pathway, but is essentially undetectable if the aguBA operon is left intact Homo sapiens
physiological function in bacteria agmatine serves as a precursor to polyamine synthesis and enhances biofilm development in some strains of the respiratory pathogen Pseudomonas aeruginosa. Agmatine is at the center of a competing metabolism in the human lung during airways infections and is influenced by the metabolic phenotypes of the infecting pathogens, e.g. Pseudomonas aeruginosa. The agu2ABCA' operon in Pseudomonas aeruginosa has a mechanism to detect extracellular agmatine and react by augmenting its biofilm. Pseudomonas aeruginosa encounters agmatine in lung infections, and this triggers planktonic pseudomonads to form a biofilm Pseudomonas aeruginosa
physiological function in humans, enzyme-produced agmatine is a neurotransmitter with affinities towards alpha2-adrenoreceptors, serotonin receptors, and may inhibit nitric oxide synthase. Agmatine exposure to inflammatory cells and in mice demonstrate its role as a direct immune activator with effects on TNF-alpha production, likely through NF-kappaB activation Mus musculus
physiological function in humans, enzyme-produced agmatine is a neurotransmitter with affinities towards alpha2-adrenoreceptors, serotonin receptors, and may inhibit nitric oxide synthase. Agmatine is at the center of a competing metabolism in the human lung during airways infections and is influenced by the metabolic phenotypes of the infecting pathogens, e.g. Pseudomonas aeruginosa Homo sapiens