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Literature summary for 4.1.1.19 extracted from

  • Tassoni, A.; Awad, N.; Griffiths, G.
    Effect of ornithine decarboxylase and norspermidine in modulating cell division in the green alga Chlamydomonas reinhardtii (2018), Plant Physiol. Biochem., 123, 125-131 .
    View publication on PubMed
Search for more literature for 4.1.1.19

Inhibitors

Inhibitors Comment Organism Structure
alpha-difluoromethylarginine DFMA, a suicide inhibitor, at 5 mM for 72 h, it inhibits ADC activity. DFMA, inhibits ADC activity in both supernatant and pellet fractions (43% and 26% respectively) Chlamydomonas reinhardtii
additional information alpha-difluoromethylornithine, DFMO, a suicide inhibitor, does not inhibit ADC activity Chlamydomonas reinhardtii

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information the enzyme is found in the soluble and the pellet fractions Chlamydomonas reinhardtii
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine Chlamydomonas reinhardtii
-
 agmatine + CO2
-
 ?
L-arginine Chlamydomonas reinhardtii CC-125
-
 agmatine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Chlamydomonas reinhardtii
-
 and CC-406 cell-wall mutant
-
Chlamydomonas reinhardtii CC-125
-
 and CC-406 cell-wall mutant
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine
-
 Chlamydomonas reinhardtii agmatine + CO2
-
 ?
L-arginine
-
 Chlamydomonas reinhardtii CC-125 agmatine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ADC
-
 Chlamydomonas reinhardtii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
 assay at Chlamydomonas reinhardtii

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Chlamydomonas reinhardtii

General Information

General Information Comment Organism
evolution ODC is the major route to polyamine formation in the Chlamydomonas CC-406 cell-wall mutant, in contrast to the preferential ADC route reported for Chlorella vulgaris, suggesting that significant species differences exist in biosynthetic pathways which modulate endogenous polyamine levels in green algae Chlamydomonas reinhardtii
metabolism putrescine is the major polyamine in both free (88%) and membrane-bound fractions (93%) in Chlamydomonas reinhardtii, while norspermidine is the next most abundant in these fractions accounting for 11% and 6%, respectively. Low levels of diaminopropane, spermidine and spermine are also observed although no cadaverine or norspermine are detected. Ornithine decarboxylase (ODC, EC 4.1.1.17) activity is almost five times higher than arginine decarboxylase (ADC) and is the major route of putrescine synthesis Chlamydomonas reinhardtii