Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.1.1.19 extracted from

  • Chintapakorn, Y.; Hamill, J.D.
    Antisense-mediated reduction in ADC activity causes minor alterations in the alkaloid profile of cultured hairy roots and regenerated transgenic plants of Nicotiana tabacum (2007), Phytochemistry, 68, 2465-2479.
    View publication on PubMed
Search for more literature for 4.1.1.19

Cloned(Commentary)

Cloned (Comment) Organism
expression of the enzyme in transformed hairy root lines in sense and antisense orientation, expression analysis Nicotiana tabacum

Protein Variants

Protein Variants Comment Organism
additional information downregulation of nicotine biosynthesis via antisense approach, diminishing of ADC activity in transformed roots, alkaloid profile of cultured hairy roots and regenerated transgenic plants, growth of transformed roots is unaltered, overview Nicotiana tabacum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine Nicotiana tabacum the enzyme is involved in biosynthesis of the important polyamine precursor putrescine, Nicotiana species also utilize putrescine to provide the pyrollidine ring of the defensive alkaloid nicotine and its derivatives in roots playing no major role, overview agmatine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Nicotiana tabacum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Nicotiana tabacum
-
root
-
 Nicotiana tabacum
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 alkaloid profile of cultured hairy roots and in leaves of transgenic and of wild-type plants, overview Nicotiana tabacum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine
-
 Nicotiana tabacum agmatine + CO2
-
 ?
L-arginine the enzyme is involved in biosynthesis of the important polyamine precursor putrescine, Nicotiana species also utilize putrescine to provide the pyrollidine ring of the defensive alkaloid nicotine and its derivatives in roots playing no major role, overview Nicotiana tabacum agmatine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ADC
-
 Nicotiana tabacum

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Nicotiana tabacum