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Literature summary for 4.1.1.19 extracted from

  • Blethen, S.L.; Boeker, E.A.; Snell, E.E.
    Arginine decarboxylase from Escherichia coli: Arginine decarboxylase from escherichia coli. I. Purification and specificity for substrates and coenzyme (1968), J. Biol. Chem., 243, 1671-1677.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2-Norpyridoxal phosphate reactivation of the apoenzyme Escherichia coli
6-Methylpyridoxal phosphate reactivation of the apoenzyme Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
2-Nor-2-butylpyridoxal phosphate
-
Escherichia coli
5-Deoxypyridoxal
-
Escherichia coli
agmatine
-
Escherichia coli
beta-(2-Methyl-3-hydroxy-4-formylpyridine-5)-propionic acid
-
Escherichia coli
citrulline
-
Escherichia coli
guanidine
-
Escherichia coli
Guanidinoacetic acid
-
Escherichia coli
L-2-Amino-3-guanidinopropanoate
-
Escherichia coli
L-2-amino-5-guanidinopentanoate
-
Escherichia coli
L-2-amino-6-guanidinohexanoate
-
Escherichia coli
L-2-Chloro-5-guanidinopentanoate
-
Escherichia coli
L-2-Hydroxy-5-guanidinopentanoate
-
Escherichia coli
L-Lys
-
Escherichia coli
methylguanidine
-
Escherichia coli
Orn L-Orn Escherichia coli
pyridoxal
-
Escherichia coli
spermidine
-
Escherichia coli
Urea
-
Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.65
-
L-Arg
-
Escherichia coli
1.2
-
L-canavanine
-
Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli B / ATCC 11303
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
350 370
-
Escherichia coli
410
-
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine
-
Escherichia coli agmatine + CO2
-
?
L-arginine
-
Escherichia coli B / ATCC 11303 agmatine + CO2
-
?
L-Canavanine
-
Escherichia coli ?
-
?
L-Canavanine
-
Escherichia coli B / ATCC 11303 ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37 40
-
Escherichia coli

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
20 50 20°C: about 40% of maximal activity, 50°C: about 70% of maximal activity Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.2
-
-
Escherichia coli

pH Range

pH Minimum pH Maximum Comment Organism
3.5 7 pH 3.5: about 50% of maximal activity, pH 7.0: 23% of maximal activity Escherichia coli

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate a formyl group of pyridoxal 5'-phosphate is bound to the 6-amino group of a Lys residue. Binds 10 mol of pyridoxal 5'-phosphate per mol of enzyme Escherichia coli