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Literature summary for 4.1.1.17 extracted from

  • Ehrnstroem, R.A.; Bjursten, L.M.; Ljungberg, O.; Veress, B.; Haglund, M.E.; Lindstroem, C.G.; Andersson, T.
    Dietary supplementation with carbonate increases expression of ornithine decarboxylase and proliferation in gastric mucosa in a rat model of gastric cancer (2008), Int. J. Cancer, 122, 727-733 .
    View publication on PubMed
Search for more literature for 4.1.1.17

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Rattus norvegicus 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Rattus norvegicus
-
 putrescine + CO2
-
 ?
L-ornithine Rattus norvegicus Wistar
-
 putrescine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P09057
-
-
Rattus norvegicus Wistar P09057
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gastric cancer cell relationship between expression level of the enzyme and mucosal proliferation, overview Rattus norvegicus
-
gastric mucosa analysis of expression of the cancer-related protein ornithine decarboxylase (ODC) in nontransformed gastric mucosa, relationship between expression level of the enzyme and mucosal proliferation, overview Rattus norvegicus
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additional information immunohistochemic expression analysis of gene ODC, the ODC protein is detected mainly in the cytoplasm of the epithelial cells in all 3 groups of animals, i.e. unoperated rats, operated rats fed a normal diet, and operated rats given a carbonate-supplemented diet, also some stromal and inflammatory cells are positively stained, overview Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
 Rattus norvegicus putrescine + CO2
-
 ?
L-ornithine
-
 Rattus norvegicus Wistar putrescine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ODC
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus carbonate ions lead to increased expression of ODC with cancer-inducing effect up

General Information

General Information Comment Organism
physiological function Ornithine decarboxylase (ODC) is the key enzyme in polyamine synthesis and a regulator of cell proliferation. ODC enhances cell proliferation in the gastric mucosa Rattus norvegicus