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Literature summary for 4.1.1.17 extracted from

  • Ohtake, Y.; Maruko, A.; Ohishi, N.; Kawaguchi, M.; Satoh, T.; Ohkubo, Y.
    Effect of retinoic acid on transglutaminase and ornithine decarboxylase activities during liver regeneration (2008), Cell Biochem. Funct., 26, 359-365 .
    View publication on PubMed
Search for more literature for 4.1.1.17

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Rattus norvegicus
-
 putrescine + CO2
-
 ?
L-ornithine Rattus norvegicus Wistar
-
 putrescine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P09057
-
-
Rattus norvegicus Wistar P09057
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
 Rattus norvegicus putrescine + CO2
-
 ?
L-ornithine
-
 Rattus norvegicus Wistar putrescine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ODC
-
 Rattus norvegicus
ODC1
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus retinoic acid suppresses ODC enzyme expression. In retinoic acid-untreated rat, ODC activity significantly increases with a peak at 1 day after partial hepatectomy, and declines thereafter. In retinoic acid-treated rats, the peak of its activity shifts to 2 days after partial hepatectomy and the amount of its peak activity is only two-thirds of that in retinoic acid-untreated rat at 1 day after partial hepatectomy down
Rattus norvegicus partial hepatectomy/liver regeneration induces ODC enzyme expression. In retinoic acid-untreated rat, ODC activity significantly increases with a peak at 1 day after partial hepatectomy, and declines thereafter. In retinoic acid-treated rats, the peak of its activity shifts to 2 days after partial hepatectomy and the amount of its peak activity is only two-thirds of that in retinoic acid-untreated rat at 1 day after partial hepatectomy up

General Information

General Information Comment Organism
physiological function ODC catalyzes the synthesis of putrescine from ornithine and is a rate-limiting enzyme in polyamine biosynthesis. The enzyme is involved in cell growth and its activity increases rapidly and markedly in regenerating liver after partial hepatectomy. Ornithine, which is a substrate of ODC, is a key metabolite in the urea cycle and the first precursor of the polyamine pathway, it increases progressively in the liver of partially hepatectomized rats, as a consequence of the increased flow of metabolites through the urea cycle. Polyamines, ODC-catalyzed products, play important roles in cell growth and differentiation due to the modification of proteins and are good substrates of transglutaminase 2 (TG2). TG2 and ornithine decarboxylase conversely regulate cell growth and differentiation, overview Rattus norvegicus