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Literature summary for 4.1.1.17 extracted from

  • Singh, K.; Coburn, L.A.; Asim, M.; Barry, D.P.; Allaman, M.M.; Shi, C.; Washington, M.K.; Luis, P.B.; Schneider, C.; Delgado, A.G.; Piazuelo, M.B.; Cleveland, J.L.; Gobert, A.P.; Wilson, K.T.
    Ornithine decarboxylase in macrophages exacerbates colitis and promotes colitis-associated colon carcinogenesis by impairing M1 immune responses (2018), Cancer Res., 78, 4303-4315 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.17

Protein Variants

Protein Variants Comment Organism
additional information construction of myeloid-specific Odc deletion mutant mice (OdcDELTAmye). Increased mRNA expression of Nos2, Tnfa, Il1b, Il12a, Ccl5 and Cxcl10 is demonstrated in dextran sulfate sodium-treated OdcDELTAmye versus Odcfl/fl mice, while expression levels of the M2 markers, Arg1 and Chil3, are comparable in colonic tissues of dextran sulfate sodium-treated Odcfl/fl and OdcDELTAmye mice. OdcDELTAmye mice are protected from colitis-associated carcinogenesis Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Mus musculus
-
 putrescine + CO2
-
 ?
L-ornithine Homo sapiens
-
 putrescine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P11926
-
-
Mus musculus P00860
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon colonic epithelial cells Mus musculus
-
colon colonic epithelial cells, the enzyme is expressed in ulcerative colitis and colitis-associated colon carcinogenesis Homo sapiens
-
epithelial cell
-
 Mus musculus
-
epithelial cell
-
 Homo sapiens
-
macrophage M1 and M2 macrophages Mus musculus
-
macrophage M1 and M2 macrophages, human colonic macrophages express increased ODC levels in active ulcerative colitis and Crohn's disease, colitis-associated dysplasia, and colitis-associated carcinogenesis Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
 Mus musculus putrescine + CO2
-
 ?
L-ornithine
-
 Homo sapiens putrescine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ODC
-
 Mus musculus
ODC
-
 Homo sapiens
ODC1
-
 Mus musculus
ODC1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Mus musculus
pyridoxal 5'-phosphate
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction myeloid-specific deletion of Odc (OdcDELTAmye) provokes a marked increase in the response of mouse bone marrow-derived macrophages to M1 stimuli including Helicobacter pylori, Citrobacter rodentium, or lipopolysaccharides plus IFN-gamma, and to increased expression of M1 genes Mus musculus
metabolism ornithine decarboxylase (ODC) is the rate-limiting enzyme for polyamine biosynthesis Mus musculus
metabolism ornithine decarboxylase (ODC) is the rate-limiting enzyme for polyamine biosynthesis Homo sapiens
physiological function polyamine biosynthesis begins with the production of the biogenic amine, putrescine, which is produced by the enzyme ornithine decarboxylase (ODC1). Ornithine decarboxylase (ODC) is the rate-limiting enzyme for polyamine biosynthesis and restricts M1 macrophage activation in gastrointestinal infections. Ornithine decarboxylase in macrophages exacerbates colitis and promotes colitis-associated colon carcinogenesis by impairing M1 immune responses, role of macrophage ODC in colonic epithelial-driven inflammation, overview. In both dextran sulfate sodium (DSS)-induced colitis and the azoxymethane (AOM)-DSS model of colitis-associated carcinogenesis, myeloid-selective loss of Odc reduces clinical disease and tumorigenesis, and this is linked to increases in the M1 response. Both an epithelial injury model and in associated carcinogenesis, M1 macrophage functions are beneficial, and ODC acts to impair this response Homo sapiens
physiological function polyamine biosynthesis begins with the production of the biogenic amine, putrescine, which is produced by the enzyme ornithine decarboxylase (ODC1). Ornithine decarboxylase (ODC) is the rate-limiting enzyme for polyamine biosynthesis and restricts M1 macrophage activation in gastrointestinal infections. Ornithine decarboxylase in macrophages exacerbates colitis and promotes colitis-associated colon carcinogenesis by impairing M1 immune responses, role of macrophage ODC in colonic epithelial-driven inflammation, overview. ODC regulates the mucosal pro-inflammatory response during acute colitis, contribution of epithelial-derived ODC to the development of dextran sulfate sodium-induced colitis Mus musculus