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Literature summary for 4.1.1.17 extracted from

  • Hayes, C.; DeFeo-Mattox, K.; Woster, P.; Gilmour, S.
    Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites (2014), Amino Acids, 46, 543-552 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.17

Protein Variants

Protein Variants Comment Organism
additional information in ODC-ER transgenic mice, in which an involucrin promoter directs the expression of the inducible ODC cDNA fused in frame to a 4-hydroxytamoxifen (4OHT)-responsive mutant estrogen receptor ligand binding domain to the suprabasal epidermis, elevated expression of ornithine decarboxylase (ODC), the regulatory enzyme in polyamine biosynthesis, targeted to the epidermis is sufficient to promote skin tumor development following a single subthreshold dose of dimethylbenz(a)anthracene (DMBA). ODC-ER transgenic mice and their normal littermates have been backcrossed into either the FVB or C57Bl/6 background for at least 10 generations. An inducible Cre-activated bi-transgenic mouse system is used to track hair follicle bulge stem cells and their progeny. K15-CrePR1 transgenic mice, that express CrePR1 under the control of a keratin 15 (K15) promoter, are generated to target expression of genes to the adult epidermal stem cells located in the hair follicle bulge cells. K15-CrePR1 transgenic mice are crossed with Cre-responsive R26R transgenic mice, that express lacZ under the control of a ubiquitous promoter, after Cre-mediated removal of an inactivating sequence. The resulting K15-CrePR1-R26R bitransgenic mice are treated topically with RU486 to induce expression of lacZ in the bulge stem cells of the skin. Polyamine oxidase inhibitor MDL72527 is applied. MDL72527 treatment increases skin tumor growth and conversion to carcinomas in DMBA-initiated ODC-ER mice, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine Mus musculus
-
 putrescine + CO2
-
 ?
L-ornithine Mus musculus C57BL/6
-
 putrescine + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P00860
-
-
Mus musculus C57BL/6 P00860
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermal cell
-
 Mus musculus
-
epidermis
-
 Mus musculus
-
skin
-
 Mus musculus
-
skin cancer cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
 Mus musculus putrescine + CO2
-
 ?
L-ornithine
-
 Mus musculus C57BL/6 putrescine + CO2
-
 ?

Synonyms

Synonyms Comment Organism
ODC
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Mus musculus

General Information

General Information Comment Organism
physiological function ornithine decarboxylase (ODC) is the regulatory enzyme in polyamine biosynthesis. Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites (reactive oxygen species) Mus musculus