Application | Comment | Organism |
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medicine | ornithine decarboxylase and sepiapterin reductase physically interact. In a cohort of 88 human neuroblastoma tumors, high sepiapterin reductase mRNA expression correlates significantly with poor survival prognosis, suggesting an oncogenic role for sepiapterin reductase in neuroblastoma tumorigenesis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
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Homo sapiens | - |
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General Information | Comment | Organism |
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physiological function | ornithine decarboxylase and sepiapterin reductase physically interact. The resulting heterocomplex is a compact structure, featuring two energetically and structurally equivalent binding modes both in monomer and in dimer conformations. siRNA-mediated knockdown of sepiapterin reductase expression significantly reduces endogenous ornithine decarboxylase enzyme activity in neuroblastoma cells | Homo sapiens |