Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-difluoromethylornithine | - |
Homo sapiens | |
alpha-difluoromethylornithine | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta thoracica | - |
Mus musculus | - |
HUVEC cell | - |
Homo sapiens | - |
umbilical vein endothelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine | - |
Mus musculus | putrescine + CO2 | - |
? | |
L-ornithine | - |
Homo sapiens | putrescine + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ODC | - |
Mus musculus |
ODC | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | ODC inhibition is associated with an abnormal morphology of the actin cytoskeleton during cell spreading and migration | Mus musculus |
malfunction | ODC inhibition is associated with an abnormal morphology of the actin cytoskeleton during cell spreading and migration. ODC inhibition in endothelial cells results in increased Cdc42 activation | Homo sapiens |
physiological function | unperturbed ODC activity is a requirement for proper microvessel sprouting | Mus musculus |
physiological function | unperturbed ODC activity is a requirement for proper microvessel sprouting ex vivo as well as the migration of primary human endothelial cells | Homo sapiens |