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Literature summary for 4.1.1.17 extracted from

  • Kucharzewska, P.; Welch, J.E.; Svensson, K.J.; Belting, M.
    Ornithine decarboxylase and extracellular polyamines regulate microvascular sprouting and actin cytoskeleton dynamics in endothelial cells (2010), Exp. Cell Res., 316, 2683-2691.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
alpha-difluoromethylornithine
-
Homo sapiens
alpha-difluoromethylornithine
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta thoracica
-
Mus musculus
-
HUVEC cell
-
Homo sapiens
-
umbilical vein endothelial cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine
-
Mus musculus putrescine + CO2
-
?
L-ornithine
-
Homo sapiens putrescine + CO2
-
?

Synonyms

Synonyms Comment Organism
ODC
-
Mus musculus
ODC
-
Homo sapiens

General Information

General Information Comment Organism
malfunction ODC inhibition is associated with an abnormal morphology of the actin cytoskeleton during cell spreading and migration Mus musculus
malfunction ODC inhibition is associated with an abnormal morphology of the actin cytoskeleton during cell spreading and migration. ODC inhibition in endothelial cells results in increased Cdc42 activation Homo sapiens
physiological function unperturbed ODC activity is a requirement for proper microvessel sprouting Mus musculus
physiological function unperturbed ODC activity is a requirement for proper microvessel sprouting ex vivo as well as the migration of primary human endothelial cells Homo sapiens